Question #1: A 30 year old woman presents to A&E with worsening headaches and blurred vision. She reports that her headaches are worst in the morning, exaggerated when she strains, and have been getting worse gradually over weeks. On examination her visual acuity is normal, her extraocular movements are normal, and there is normal tone, power, and reflexes throughout all four limbs. On fundoscopy you notice that she has bilateral papilloedema. She has a BMI of 35, takes the oral contraceptive pill, but has no other medical history of note. What is the most likely diagnosis?

Question #2: A 64 year old man with Multiple System Atrophy suffers from postural hypotension. What is the most appropriate first-line drug therapy?

Question #3: A 68 year old man is referred to neurology clinic because his wife noticed a tremor in his right hand. On questioning she mentions that he has not been ‘quite right’ for some time, especially at night time. Which of the following is a recognised prodromal feature of Parkinson’s Disease?

Question #4: What is the mode of inheritance of Friedrich’s ataxia?

Question #5: A 56 year old man with known ALS presents to A&E having become increasingly short of breath over the last few weeks. His breathing is now so bad that he cannot get dressed without getting of breath. What acid-base abnormality on arterial blood gas best fits this presentation?